RESUMO Os resíduos industriais e orgânicos causam impactos ambientais em diversos níveis. No entanto, apresentam potencial para a correção da acidez e a fertilização do solo. A partir da possibilidade de utilização destas fontes alternativas, objetivou-se analisar a qualidade de sementes de jiló produzidas com o uso de resíduos industriais. O experimento foi desenvolvido em casa de vegetação sendo utilizadas sementes de jiló (Solanum gilo), cv. ‘Verde-Claro’. O solo utilizado é um Latossolo Vermelho-Amarelo distrófico. O delineamento experimental utilizado foi em blocos casualizados, com distribuição fatorial (3x4x5), sendo três variações de solo [solo puro (S), solo + esterco bovino (SE) e solo + lodo de esgoto (SL)], quatro tratamentos corretivos [sem correção (C1), calcário (C2), escória de siderurgia (C3) e pó de mármore (C4)], e cinco períodos de armazenamento das sementes (0, 100, 120, 140 e 160 dias). O uso de escória de siderúrgica e pó de mármore associados à adição de lodo de esgoto e esterco bovino aumentou as massas fresca das plantas, em 40%, e seca, em 48%, quando comparadas com o solo puro. Após 140 dias de armazenamento há efeitos negativos no vigor das sementes de jiló.

ABSTRACT Industrial and organic residues cause environmental impacts at various levels. However, these residues present potential to correct soil acidity and fertility. Considering the possibility of using these alternative sources, the objective of this study was to analyze the quality of scarlet eggplant seeds produced with the use of industrial waste. The experiment was carried out in a greenhouse. We used scarlet eggplant seeds (Solanum gilo), cv. ‘Verde-Claro’, and the soil was Typic Hapludox. The experimental design was randomized blocks, in a factorial distribution (3x4x5), being three soil variations [(pure soil (S), soil + cattle manure (SE) and, soil + sewage sludge (SL)], four corrective treatments [without correction (C1), limestone (C2), steel slag (C3) and marble powder (C4)], and five periods of seed storage (0, 100, 120, 140 and 160 days). The use of steel slag and marble powder associated with the addition of sewage sludge and cattle manure increased fresh mass of plants, at 40%, and dry mass of plants, at 48%, when compared with the pure soil. After 140 day of storage, negatives effects on the vigor of scarlet eggplant seeds could be noticed.

OBJETIVO: Investigar a eficácia de uma nanoemulsão transdérmica de testosterona associada à terapia com estrogênio transdérmico como tratamento para a perda emergente da libido. MÉTODOS: Vinte e quatro mulheres, com idade entre 31-75 anos (idade média de 51,7), com perda emergente de libido foram incluídas num protocolo para tratamento de libido reduzida com uma formulação transdérmica de 500 µg/dia de testosterona (biolípido/B2®-testosterona) com 12 semanas de duração, como parte de um estudo prospectivo aberto em mulheres peri- e pós-menopausa. As participantes aplicaram a formulação no antebraço direito. Os parâmetros clínicos e laboratoriais, incluindo as queixas sexuais foram comparados entre os valores iniciais e 12 semanas após o tratamento. Mediram-se as concentrações séricas de testosterona, insulina, proteína C-reactiva, o peso, a pressão arterial; o índice de massa corporal e a circunferência da cintura. RESULTADOS: A média de testosterona total no soro aumentou significativamente (p = 0,009) após 12 semanas de tratamento. Não foram observados efeitos adversos ou androgênicos. Registraram-se reduções significativas (p < 0,05) sobre as queixas sexuais, da pressão arterial, do índice de massa corporal e da circunferência da cintura após o tratamento transdérmico com nanoemulsão de testosterona. CONCLUSÃO: O protocolo mostrou eficacia em aumentar os níveis de testosterona em e melhorar a libido em mulheres peri e pós-menopausa com baixa libido.

OBJECTIVE: To investigate the efficacy of a transdermal nanoemulsion testosterone associated with transdermal estrogen therapy as a novel protocol treatment for emergent loss of libido. METHODS: Twenty-four women, aged 31-75 years (mean age, 51.7), with emergent loss of libido were allocated to treatment with a novel transdermal formulation of 500 µg/day of testosterone (Biolipid/B2®-testosterone) for 12 weeks, as part of an open label prospective study on peri- and post-menopausal women. Subjects applied the formulation on the right forearm. Clinical and laboratorial parameters including the sexual complaints; serum concentrations of testosterone, insulin, C-reactive protein, weight, blood pressure; body mass index and waist circumference were compared between baseline and 12 weeks after treatment. RESULTS: The mean total serum testosterone increased significantly (p = 0.009) after 12 weeks of treatment. No adverse or androgenic events were observed. There were positive and significant differences (p < 0.05) on sexual complaints, blood pressure, body mass index and waist circumference after transdermal nanoemulsion testosterone treatment. CONCLUSION: This protocol is effective in increasing testosterone levels in peri- and postmenopausal women with low libido.

OBJECTIVE: To determine the safety and efficacy of a transdermal nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) for relieving postmenopausal symptoms. METHODS: A total of 66 postmenopausal Brazilian women with climacteric symptoms of natural menopause received transdermal nanostructured formulations of progesterone and estrogens in the forearm daily for 60 months to mimic the normal ovarian secretory pattern. Confocal Raman spectroscopy of hormones in skin layers was performed. Clinical parameters, serum concentrations of estradiol and follicle-stimulating hormone, blood pressure, BI-RADS classification from bilateral mammography, and symptomatic relief were compared between baseline and 60 months post-treatment. Clinicaltrials.gov: NCT02033512. RESULTS: An improvement in climacteric symptoms was reported in 92.5% of women evaluated before and after 60 months of treatment. The serum concentrations of estradiol and follicle-stimulating hormone changed significantly (p<0.05) after treatment; the values of serum follicle-stimulating hormone decreased after 60 months from 82.04±4.9 to 57.12±4.1 IU/mL. A bilateral mammography assessment of the breasts revealed normal results in all women. No adverse health-related events were attributed to this hormone replacement therapy protocol. CONCLUSION: The nanostructured formulation is safe and effective in re-establishing optimal serum levels of estradiol and follicle-stimulating hormone and relieving the symptoms of menopause. This transdermal hormone replacement therapy may alleviate climacteric symptoms in postmenopausal women.

O experimento foi conduzido em casa de vegetação na UFES-CCA, em Alegre-ES, objetivando avaliar a produção de brócolos em função do sistema de produção da semente e do tipo de substrato. Utilizaram-se sementes de brócolos da cultivar Ramoso Piracicaba. O delineamento foi em blocos ao acaso, com quatro repetições, em arranjo fatorial 2x5, compreendendo lotes (sementes de cultivo orgânico e convencional) e substratos [S1 (solo + areia + esterco); S2 (solo + areia + esterco + NPK); S3 (solo + areia + esterco + Fertium® 10 g L-1); S4 (solo + areia + esterco + Fertium® 30 g L-1) e S5 (solo + areia + esterco + Fertium® 50 g L-1)]. Foram avaliados a emergência, massa fresca e seca da parte aérea, IVE e altura de plântulas após 28 dias da semeadura; e diâmetro do colo, área foliar, número de folhas, massa fresca e seca da parte aérea, altura das plantas, volume de raiz, massa fresca e seca da raiz, taxas de crescimento absoluto e relativo e incremento para área foliar e altura das plantas após 104 dias. A emergência foi similar nos diferentes substratos. As sementes de sistemas convencionais apresentaram maior vigor; a adubação mineral aumentou a produção de massa fresca da parte aérea; a utilização de substrato contendo solo, areia, esterco e o condicionador de solo Fertium (30 a 50 g L-1) aumentou o volume, massa fresca e seca da raiz das plantas e a taxa de incremento nestas variáveis.

The experiment was conducted in a greenhouse at the Universidade Federal do Espirito Santo, in Alegre, Espirito Santo state, Brazil, to evaluate the broccoli production depending on the seed production system and organic and mineral fertilization. Seeds of the broccoli cultivar Ramoso Piracicaba were originated from lots of seed obtained in an organic and conventional production system. The experimental design was of randomized blocks, with four replications in a factorial arrangement combination of the lots, 2x5 (organic and mineral fertilized seeds) and substrates [S1 (soil + sand + manure), S2 (soil + sand + manure + NPK), S3 (soil + sand + manure + Fertium® 10 g L-1), S4 (soil + sand + manure + Fertium® 30 g L-1) and S5 (soil + sand + manure + Fertium® 50 g L-1]. The analyzed variables were emergency, fresh and dry mass of aerial part, emergency speed and height of seedlings after 28 days of sowing, and plant diameter, leaf area, number of leaves, fresh and dry mass of aerial part, plant height, root volume, fresh and dry root mass, absolute and relative growth rates and increment to leaf area and plant height after 104 days. The emergency was similar in the different substrates; great vigor occurred on conventional seeds; the mineral fertilization increased the production of fresh mass of aerial part; the use of substrate containing soil, sand soil conditioner Fertium (30 to 50 g L-1) increased the volume, fresh and dry mass of roots and rate of increase in these variables.